OncoStrands® Comprehensive > DNA Laboratories Staging Site

Specimen Requirements
Clinical usage	Based on TSO 500 chemistry, the assay offers a comprehensive genomic analysis of 523 genes and targets single nucleotide variations (SNVs), CNVs, fusions, splice variants, MSI and tumour mutation burden (TMB). The assay provides coverage of NCCN biomarkers testing guidelines, genes associated with FDA-approved targeted therapies and clinical trials matching for a variety of tumours. NOTE: Can be ordered with Homologous recombination deficiency (HRD) for early to late-line PARPi treatment decisions for patients with ovarian cancer.
Type of sample	Formalin-fixed paraffin-embedded (FFPE) Tissue / Cell Block (preferred) or 15 x 5µm unstained slides of FFPE tissue mounted on uncoated slides + 1 H&E stained slide
Surface Area & Tumour Purity	Minimum surface area of 5 x 5 mm2 per slide. If the tissue area is smaller, please provide additional 5-10 5µm unstained slides. At least 20% tumour purity per slide.
Storage & transportation	Please keep at room temperature. Do not freeze, and keep away from direct sunlight.
Turnaround Time (TAT)	3 – 4 weeks

Specimen Requirements

Clinical usage

Based on TSO 500 chemistry, the assay offers a comprehensive genomic analysis of 523 genes and targets single nucleotide variations (SNVs), CNVs, fusions, splice variants, MSI and tumour mutation burden (TMB). The assay provides coverage of NCCN biomarkers testing guidelines, genes associated with FDA-approved targeted therapies and clinical trials matching for a variety of tumours.

NOTE: Can be ordered with Homologous recombination deficiency (HRD) for early to late-line PARPi treatment decisions for patients with ovarian cancer.

Type of sample

Formalin-fixed paraffin-embedded (FFPE) Tissue / Cell Block (preferred) or 15 x 5µm unstained slides of FFPE tissue mounted on uncoated slides + 1 H&E stained slide

Surface Area & Tumour Purity

Minimum surface area of 5 x 5 mm2 per slide. If the tissue area is smaller, please provide additional 5-10 5µm unstained slides. At least 20% tumour purity per slide.

Storage & transportation

Please keep at room temperature. Do not freeze, and keep away from direct sunlight.

Turnaround Time (TAT)

3 – 4 weeks