Y-chromosome deletion testing is a molecular genetic test used to detect small deletions in the azoospermia factor (AZF) regions of the Y chromosome, which are critical for normal sperm production. These deletions are a common cause of non-obstructive azoospermia and severe oligozoospermia in men with unexplained infertility.

Y-chromosome deletion test detects deletions of one or more sequences in the three specific regions on the long arm of Y chromosome, known as “azoospermia factors”(AZF) loci: AZFa, AZFb and AZFc.

Identifying Y-chromosome deletion can aid in diagnosis, prognosis, and management of male infertility, particularly before initiating assisted reproductive techniques such as intracytoplasmic sperm injection (ICSI).

Advantages of the test

• Requires only a blood sample, making it a simple and accessible genetic test.
• Early identification allows for timely reproductive planning and consideration of an assisted reproductive techniques if necessary